Yes, the effects of Botox are not permanent, and do wear off. But the way to look at this is to consider that you are buying time each time you do Botox as each treatment helps prevent or slow wrinkle creation. Usually you can see the results last up to 3-6 months depending upon your metabolism and how many units of Botox is injected. Areas of the body that use muscles more frequently, like near the mouth, may have a shorter effect especially since the number of units delivered in this area is usually less than on the forehead region.